“Amazing result. I had surgery in the afternoon and walked out without pain late afternoon. Two weeks later the stitches are out, swelling reduced and normal knee function restored. A master craftsman and highly recommended.”

“Excellent service - always on time for the appointment. Problem well explained and treatment excellent during the operation and time spent in the hospital. Follow up treatment with consultant and physiotherapists also excellent.”

“Having your knee replaced is a very painful procedure but I've worked hard at getting back to normal and I do feel that the fabulous surgery was an integral part of my speedy recovery. Mr. Bradbury is a super surgeon! He does an amazing job.”

“Mr. Bradbury is an excellent surgeon. He has now fixed both of my knees. The whole hospital experience is amazing and will always be my first choice for any future surgical procedures.”

“Just thought I would let you know that I had a very successful weeks skiing in Verbier and got back last weekend. Weather fantastic and knee held up very well. Many, many thanks.”

“I couldn't ask for a better surgeon than Neil, he has honestly changed my life in 1 year and I can't thank him enough.”

“I would sincerely like to thank you and your team for the work you did on my knee after the x-ray revealed a 'nasty' break. Your expertise has given me back the use of this leg and I can now walk unaided for half a mile or more. The previous knee operation has also been a complete success.”

“The process from start to finish was smooth and efficient. I always knew where I was in the process, what to expect and when. A thoroughly professional service with a smile.”

“Pre-op information first class. Post-op conditions also first class. Very successful operation.”

Regenerative surgery

Regenerative surgery

 

Intra-articular protein therapy

nSTRIDE Autologous Protein Solution (APS) therapy is a form of regenerative surgery using a patient’s own blood. The treatment is designed to treat pain and slow the progression of cartilage degradation and destruction of the knee in patients with osteoarthritis.

This groundbreaking procedure involves the extraction of blood from the patient, separation in a centrifuge to obtain a concentrated suspension of platelets via plasmapheresis, followed by injection of part of the fluid into the knee.

To find out more about regenerative surgery click here.

Osteoarthritis

Osteoarthritis, the most common type of arthritis is a progressive disease of the joints. Osteoarthritis occurs when the top layer of cartilage, the slippery tissue that covers the ends of the bones in a joint and help absorb the shock of movement, breakdown and wears away. This causes the bones to rub together causing pain, swelling and less comfortable movement. Later stages in the disease cartilage will disintegrate and subchrondral microfractures will expose the bony surface.

Protein Injections

So once osteoarthritis pain starts it is hard to stop. The nSTRIDE APS Kit is designed to produce a groundbreaking autologous therapy to treat pain and slow the progression of cartilage degradation and destruction in the knee.

The nSTRIDE APS Kit is a self-contained, sterile-packaged, single-use device system. It is designed to separate anti-inflammatory cytokines and growth factors from whole blood. The device system is to be used at the point of care to create an autologous solution.

The nSTRIDE APS Kit uses a small sample of the patient’s own blood to create an autologous solution. This device system consists of two parts: the nSTRIDE Cell Separator and the nSTRIDE Concentrator. The nSTRIDE Cell Separator utilizes centrifugal force to process the blood sample and separate the cellular components from plasma and red blood cells. This step takes 15 minutes. The cell suspension is then loaded into the nSTRIDE Concentrator, which uses centrifugal filtration through polyacrylamide beads to concentrate the injectable output. This step takes 2 minutes.

The final product contains concentrated white blood cells, platelets, and plasma proteins in a small volume of plasma. The output is approximately a 2 to 3 cc anti-inflammatory solution.

The proposed APS mechanism of action is a process of reducing OA-related upregulated inflammatory cytokines by introducing antagonistic cytokines, which inhibit the inflammatory cytokine activity. APS has been shown to reduce production of proteins associated with osteoarthritic inflammation and pain responses in vitro.

There is growing evidence to support its use for select indications in osteoarthritis (Kellgren-Lawrence Grade 2-3).  Clinical studies have demonstrated the effectiveness of one single injection. Studies suggest one injection can last at least 12 months, with new evidence shows evidence upto 2 years post injection.

How is nSTRIDE APS given?

The 2 – 3 cc of fluid concentrate is injected directly in the knee joint.

Are there any side effects?

You may experience side effects (e.g. bruising, local pain or swelling) associated with the blood draw, knee injection, MRI or X-Ray procedures.

Will nSTRIDE APS cure my osteoarthritis?

There is no cure for osteoarthritis however successful treatment with nSTRIDE APS may reduce or relieve your pain increasing your mobility and comfort. Your osteoarthritis may not improve or may get worse.

When will the treatment start to work?

Pain relief can be expected after one week.

How long can I expect the benefits to last?

Based on preclinical and early clinical results, patients should expect to see benefits for at least 12 months.